In previous studies, the NF-kappaB and MEK/ERK signaling pathways have been shown to contribute to the regulation of SOCS3 expression (Pauli et al., 2008; Borland et al., 2009; Ehlting et al., 2015), and the role of the MEK/ERK signaling pathway in inducing SOCS3 expression during virus infection has rarely been reported. This evidence concerns the gene SOCS3 and viral infectious disease.