We have identified several CRC-related pathways, such as “Cell cycle,” “DNA replication,” “Nod like receptor signaling pathway,” “Nucleotide excision repair,” “P53 signaling pathway,” “RNA degradation,” “Spliceosome,” and “Ubiquitin mediated proteolysis” pathways, which were significantly enriched in the high risk group. The gene discussed is TP53; the disease is colorectal carcinoma.