PTK2 and breast cancer: Up expression was correlated with metastasis in breast cancer. In normal breast cells, MIEN 1 expression levels was comparatively low. Induces FAK phosphorylation (Tyr-925) and reduces cofilin phosphorylation at Ser-3 residue. This results in cancer cell migration. Maintains the plasticity of the dynamic membrane-associated actin cytoskeleton in term of F-actin polymerization, stabilization and ultimately increases cell motility.