Similar inhibitory effects of NM on tryptase-induced cell proliferation were observed in pancreatic cancer by Guo et al. They also demonstrated that NM possessed the ability to reverse tube formation caused by tryptase via inhibiting the expression of angiogenesis-related genes, angiopoietin-1 (ANGPT1) and TIE2 (26). This evidence concerns the gene ANGPT1 and familial pancreatic carcinoma.