Furthermore, numerous studies have reported that NM plus chemotherapeutic agents or IR triggers expression of cleaved caspase-8, caspase-3, caspase-9, and PARP compared to using chemotherapy or IR alone in pancreatic, colorectal, gastric, gallbladder, and hepatocellular cancer, closely followed by downregulation of various forms of NF-κB (15, 16, 18, 20–22, 24, 25). This evidence concerns the gene NFKB1 and hepatocellular carcinoma.