In stroke rat models, NM decreased the generation of proinflammatory factors TNF-α, interleukin-1β (IL-1β), inducible nitric oxide synthase and cyclo-oxygenase-2, and elicited the expression of anti-inflammatory mediators CD206, TGF-β, IL-10, and IL-4 (63). Here, NOS2 is linked to stroke disorder.