In line with our study, downregulation of AEG-1 by miR-375 in hepatocellular carcinoma, breast cancer, head and neck squamous cell carcinoma, esophageal cancer and adrenocortical carcinoma led to inhibition of cancer cell growth, proliferation and invasiveness (29, 30, 47–49). The gene discussed is MTDH; the disease is breast carcinoma.