MTA3 and cancer: Therefore, we next explored the relationship between MTA3 level and cancer cell stemness using gene set enrichment analysis (GSEA) of published human TSCC expression profiles (GSE78060) and found that a cancer stemness related gene signature (BOQUEST_STEM_CELL_UP) was significantly enriched in TSCC with low MTA3 expression (P < 0.001, Figure 3A).