Serine and arginine-rich splicing factor 1 (SRSF1) and heterogeneous nuclear ribonucleoprotein K (hnRNPK) were aberrantly upregulated in pancreatic cancer, leading to the increased expression of anti-apoptotic splice variants of Bcl-x and Mcl-1, significantly affected responses to chemotherapy (19). The gene discussed is HNRNPK; the disease is pancreatic neoplasm.