The PheWAS reveals that the top sIL6R variant, rs4129267 (PGWAS  = 7.41 × 10−1101), was associated with monocyte count (PPheWAS  = 2.97 × 10−15), mean platelet volume (MPV) (PPheWAS = 9.03 × 10−11), and atopic disorders such as atopic dermatitis/eczema (AD) (PPheWAS = 1.19 × 10−8) and asthma (PPheWAS  = 3.79 × 10−7) (Fig. 4a). Here, IL6R is linked to atopic eczema.