For instance, plasma IL6 level has been positively associated with the risk of AF and left atrial dimension.24 Candidate gene approaches have identified nominally significant gene variants in IL6R that were associated with AF.12,13 In the present work, we leveraged summary-level data of a large GWAS with more than a million individuals to map IL6R to AF. The gene discussed is IL6; the disease is atrial fibrillation.