Moreover, sIL6R was also inversely and causally associated with every stroke subtypes (LA-stroke, OR: 0.968; 95% CI: 0.938–0.999; Pcausal = 0.041; SV-stroke, OR: 0.95; 95% CI: 0.92–0.98 Pcausal = 8.13 × 10−4; AI-stroke, OR: 0.98; 95% CI: 0.96–0.99; Pcausal = 7.38 × 10−4; and CE-stroke, OR: 0.95; 95% CI: 0.92–0.98; Pcausal = 1.42 × 10−3) (Fig. 3b). Here, IL6R is linked to stroke disorder.