INVS and cancer: Terpenoids and polyketides are examples of secondary metabolites with potential for development as antimicrobial, immunomodulatory, cytotoxic, anti-inflammatory, anti-oxidant, or anti-cancer products.73 We found a negative correlation between polyketide and terpenoid metabolism and transcription of ITGA4, PLCD1, DNAJA3, EML6, and COL18A1, and a positive correlation with INVS, EIF2S3L, and SH3BGRL, many of which have been implicated in inflammation via crosstalk between pathways.