CHDH and coronary artery disorder: Genes that interact with established CHD proteins NKX2-5 and GATA4 had singular de novo CNVs encompassing DUSP1, JUN, JUP, MED15, MED9, PTPRE SREBF1, TOP2A, and ZEB2. However, due to limited sample sizes, platform limitations, and inadequate control sets, significant potential to identify new CHD-related genes exists, especially for de novo genomic CHD CNVs.