BCL2L1 and cancer: In cancer, a commonly reported therapeutic effect of SSOs is of targeting the Bcl-x pre-mRNA to redirect splicing from Bcl-xL to Bcl-xS, resulting in pro-apoptotic and chemosensitizing effects in various cancer cell lines (Mercatante et al., 2002; Bauman et al., 2009; Bauman et al., 2010; Li et al., 2015).