It is worth to mention that the role of tumor-associated macrophages in promoting PI3K/Akt/mTOR signaling in malignant cells has been reported (Dwyer et al., 2017; Zhang et al., 2017; Zheng et al., 2018; Ye et al., 2018), which corresponds to our results regarding the role of this signaling in LL. Here, AKT1 is linked to neoplasm.