MAP3K8 was identified as an oncogene in endometrial cancer, breast cancer, colon cancer, renal cancer, gastric cancer, and nasopharyngeal carcinoma (Lee et al., 2015), but it is a tumor suppressor gene in lung and intestinal cancers (Gkirtzimanaki et al., 2013; Zhang et al., 2016) as well. This evidence concerns the gene MAP3K8 and malignant colon neoplasm.