RASSF2 was reported to be associated with ovarian endometriosis, breast cancer, gastric cancer, and childhood acute lymphoblastic leukemia (Ren et al., 2014; Perez-Janices et al., 2015; Aydin et al., 2016; Singh et al., 2016) and has been proposed as a novel methylation marker for screening several cancers (Cooper et al., 2008). The gene discussed is RASSF2; the disease is acute lymphoblastic leukemia.