This is not the case of the most common sporadic AD forms, characterized by late onset (age > 65), representing about 95% of AD cases (Bali et al., 2012), for which the “4 allele of Apolipoprotein E (APOE) is the only strong identified genetic risk factor (Dorszewska et al., 2016). This evidence concerns the gene APOE and Alzheimer disease.