SHH and acute lymphoblastic leukemia: Recently, in patients with T-cell acute lymphoblastic leukemia (T-ALL), several mutations of SHh signaling are described (Dagklis et al., 2016), and loss of Ptch1 function is able to empower T-ALL development Notch1-dependent, demonstrating that Hh pathway activation is an oncogenic driver in the molecular pathogenesis of T-ALL (Burns et al., 2018).