Notably, the Ptch1 knock-out mouse model develops tumors similar to Gorlin syndrome patients, like BCC, MBs, and sporadic rhabdomyosarcomas, providing evidence about the driver role of Hh signaling for cancer development (Hahn et al., 1996; Nitzki et al., 2011). The gene discussed is PTCH1; the disease is nevoid basal cell carcinoma syndrome.