LEF1 and chronic myelogenous leukemia, BCR-ABL1 positive: Intriguingly, the ability of Hh to crosstalk with Wnt is suggested by Sengupta and coworkers, who demonstrated that Hh signaling via Stat3 activation gives rise to the expression of Wnt3a, Lef1, Gli1–3, and other target genes in the chronic phase of chronic myeloid leukemia (CML) (Sengupta et al., 2007).