Although, depletion of total CD4+ or CD8+ cells in mdx mice ameliorates the histopathology (37) this would not be a potential treatment for DMD patients and no other MAb-based tolerizing treatment used in organ transplantation, GVHD or autoimmunity, such as anti-CD3, anti-CD127, anti-CD28, has been previously used in DMD models. Here, CD4 is linked to Duchenne muscular dystrophy.