IL6 and Sepsis: We report here that CLP-sepsis leads to a significant increase in the serum levels of the pro-inflammatory cytokines TNF-α, IL-6, IFN-γ, anti-inflammatory cytokines IL-10, IL-4 and the chemokines KC/CXCL1, eotaxin-1/CCL11, eotaxin-2/CCL24, all of which importantly contribute to the local and systemic inflammation and organ injury associated with sepsis (33).