When compared to sham operated mice, CLP-sepsis (vehicle-treatment) resulted in the increased expression of the NLRP3 inflammasome and cleavage of pro-caspase-1 to caspase-1 in the heart and a rise in serum IL-1β (P < 0.0001; Figures 5A–C). Here, NLRP3 is linked to Sepsis.