Nevertheless, autoreactive IgE can be found also in other inflammatory skin diseases [for a review see (14)]: For example, patients suffering from bullous pemphigoid are IgE-(as well as IgG- and IgA-)sensitized against the hemidesmosomal proteins BP180 (BP antigen 2) and BP230 (BP antigen 1). Here, IGHE is linked to bullous pemphigoid.