Interestingly, a subset human CD4 T cells, which is CD45RA+CCR7− and termed effector memory re-expressing CD45RA T (Temra) cells, expands in individuals that have been infected with DENV multiple times, and the frequency of DENV-specific CD4 Temra cells is higher in donors expressing an HLA allele associated with protection from severe dengue disease (26). The gene discussed is CD4; the disease is dengue disease.