ITGB2 and hyperinsulinemic hypoglycemia, familial, 4: Furthermore, this facilitated the identification of female carriers of some X-linked traits, such as XLP-1, XLP-2, and XLA (51, 55–57, 59) (Figure 2), as well as the discovery of somatic reversion in XLP-1 (60), DOCK8-deficiency (54), and leukocyte adhesion deficiency-1 due to mutations in ITGB2 encoding CD18 (61, 62).