In this study, we showed that BLM-induced scleroderma stimulated infiltration of CD68-positive macrophages into scleroderma skin, and the serum levels of the inflammatory cytokines, TNF-α and INF-γ, were up-regulated in the scleroderma model; however, WKYMVm treatment attenuated these effects. Here, CD68 is linked to scleroderma.