Moreover, the numbers of M1 macrophages including CD68+NOS2+ and CD68+TLR2+ populations increased in BLM-induced scleroderma skin; however, the BLM-induced increase of M1 macrophage (CD68+NOS2+ and CD68+TLR2+) populations was not significantly affected by WKYMVm treatment (Figures 4C,D,G). Here, NOS2 is linked to scleroderma.