Further studies are needed to elucidate the meaning of alternative NF-κB-induced changes to gastrointestinal immunity to C. rodentium, however the results of this study highlight the deleterious effect that pathogen-induced classical NF-κB signaling within epithelial and myeloid-derived cells can have during gastrointestinal infection. The gene discussed is NFKB1; the disease is digestive system infectious disorder.