TLR7 and systemic lupus erythematosus: Using TLR8ko mice on the C57BL/6 background that develop lupus due to increased TLR7 expression and signaling by dendritic cells (26, 28), our data clearly demonstrate that HFD leads to exacerbation of lupus autoimmunity and metabolic parameters and these phenomena could be attributed to increased TLR7 expression and signaling (Figure 7).