Fatty liver is characterized by excessive triglyceride deposition as lipid droplets in hepatocytes that trigger mitochondrial oxidative stress and hepatic inflammation with increased TNF, IL-6, and IL-1β, cytokine production, which are considered as critical factors leading to the progression from benign hepatic steatosis to advanced steatohepatitis or even fibrosis and cirrhosis (12). Here, IL1B is linked to fatty liver disease.