Fatty liver is characterized by excessive triglyceride deposition as lipid droplets in hepatocytes that trigger mitochondrial oxidative stress and hepatic inflammation with increased TNF, IL-6, and IL-1β, cytokine production, which are considered as critical factors leading to the progression from benign hepatic steatosis to advanced steatohepatitis or even fibrosis and cirrhosis (12). The gene discussed is TNF; the disease is fatty liver disease.