Currently, the physiological roles in tumor surveillance by NK cells, as well as the therapeutic potential, of many surface receptors on NK cells have been demonstrated (e.g., KIR, TIGIT, NKG2A, CD96, and PD-1), while those of many others still remain to be shown (e.g., LAG-3 and TIM-3). The gene discussed is CD96; the disease is neoplasm.