In addition, investigating the role of Cdk8/Cdk19 inhibition on other autoimmune diseases such as graft-vs.-host disease, SLE, and rheumatoid arthritis (RA) will further confirm the function of Cdk8/Cdk19 in adaptive immunity regulation and diversify its application in the field of autoimmunity. Here, CDK8 is linked to rheumatoid arthritis.