Collectively, these data suggest that the lack of IFN impacted the ability of mice to deal with M. africanum infection, but in contrast to M. tuberculosis infections (Cooper et al., 1993; Nandi and Behar, 2011; Moreira-Teixeira et al., 2016), it did not lead to overt disease and premature death, at least during the first 90 days of infection. Here, IFNA1 is linked to infection.