IFNG and infection: IFN-γ–/– mice infected with M. tuberculosis typically succumb to infection during the first 40 days (Cooper et al., 1993; Nandi and Behar, 2011; Moreira-Teixeira et al., 2016), whereas humans with mutations in the IFN-γ producing/responding axis present Mendelian susceptibility to mycobacterial disease (Abel et al., 2018).