NLRP3 has been associated with the development of cancer, atherosclerosis (Varghese et al., 2016), currently viewed as predictor for chronic myeloid leukemia (Zhang et al., 2018) and novel diagnostic biomarker for early detection for diabetic nephropathy (El-Horany et al., 2017). The gene discussed is NLRP3; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.