In particular in many tumor type, including OC, it has been reported that ET-1 activating the ET-1R, both expressed by fibroblasts isolated by normal tissues near to cancer tissues, promote their growth, migration and contraction, as well as the production of ECM modifying factors (40), suggesting that such cross-talk may take place through the paracrine release of ET-1 that, fostering the formation of a prone tumor stroma, participates to create a niche that support tumor maintenance. This evidence concerns the gene EDN1 and neoplasm.