Regarding the ability of β-arr1 to interconnect oncogenic signaling pathways, a recent study discloses the interplay between ET-1R/β-arr1 axis and the Hippo transducers YAP and TAZ in patient-derived high-grade serous ovarian cancer (HG-SOC) cells and in breast cancer cell lines carrying TP53 mutations (mutp53) (33), indicating a therapeutic option for the treatment of mutp53 cancers and opening new prospects on the regulation of YAP/TAZ biology (34, 35). Here, TP53 is linked to breast cancer.