Since PKC activation of MAPK and PI3K/Akt cascades has also been documented, e.g., in curcumin prevention of diabetic cardiomyopathy (70) and actin remodeling in chemotaxing ameboid cells (71), the possibility of PKC crosstalk with MAPK and PI3K/Akt cascades in the hepatic actions of glucagon cannot be excluded. This evidence concerns the gene PRRT2 and diabetic cardiomyopathy.