Based on our finding that BPA exposure increased acute myocarditis in female BALB/c mice (Figure 1), these data suggest that ERα signaling reduces while ERβ signaling increases our model of autoimmune CVB3 myocarditis- confirming the role for these receptors that have been shown previously by Huber et al. using a different model of CVB3 myocarditis (10). Here, ESR1 is linked to myocarditis.