Next we determined expression of collagen genes in the heart during myocarditis and found that BPA exposure in drinking water significantly increased expression of collagen I (Col1a1) (p = 0.005) (Figure 9C) and collagen III (Col3a1) (p = 0.02) (Figure 9D) compared to control water. The gene discussed is COL3A1; the disease is myocarditis.