A recent study shows that in lung cancer cells, sirtuin 4 (SIRT4, an nicotinamide-adenine dinucleotide+ (NAD+)-dependent protein deacetylase) inhibits Drp1 phosphorylation at the S616 site and weakens Drp1 recruitment to the mitochondrial membrane via an interaction with Fis1 (122). Here, DNM1L is linked to lung carcinoma.