Since misfolded tau aggregates in AD and CTE were replicated in cells expressing both 3R- and 4R-tau isoforms, but not cells expressing either 3R-tau or 4R-tau, the propagation properties of misfolded tau aggregates in AD and CTE are distinct from those in Pick's disease and PSP (22). The gene discussed is MAPT; the disease is supranuclear palsy, progressive, 1.