Modulation in CTGF and COL1A1 gene expression has been previously reported after tendon perturbations such as exercise (net collagen degradation after 24–36 h followed by net synthesis by up to 72 h) (Magnusson et al., 2010) and tendinopathies models (reduction in COL1A1 both 24 and 72 h of glutamate exposure) (Dean et al., 2015). This evidence concerns the gene CCN2 and disease of the tendon.