Median CRP within 24 h from the onset of pain were significantly lower in mild 8.90 (IQR: 3.60–25.10) mg/l and moderately severe 14.60 (IQR: 4.15–60.46) mg/l, than in severe AP 51.45 (IQR: 7.85–175.53) mg/l (mild vs. moderately severe AP: P = 0.006; mild vs. severe AP: P < 0.001; moderately severe vs. severe AP: P = 0.059) (Figure 2A). The gene discussed is CRP; the disease is alkaline phosphatase measurement.