APP and Alzheimer disease: Preclinical studies aimed at elucidating the role of glucocorticoids as a risk factor for AD have been mostly conducted in transgenic (Tg) mice, such as Tg2576 mice expressing human APP carrying the Swedish mutation (KM670/671NL), mice with a double mutations of APP and PSEN1, and 3xTgAD mice, characterized by a triple mutations of APP (Swedish mutations), PSEN1 (M146V), and the P301L mutation in the gene encoding tau protein (MAPT) (Götz et al., 2018).