Nevertheless, LEP and DPEP markedly inhibited mRNA levels of genes mentioned above, indicating that LEP and DPEP had protective effects on infected mice by regulating the mRNA expression of TLR3, TLR4, TLR7, MyD88, NF-κB p65 and RIG-1 to lighten inflammation and improve immune function with the development of influenza virus-induced pneumonia. Here, PLAAT4 is linked to susceptibility to pneumonia measurement.