MTOR and cancer: In terms of therapies for glioblastomas, eukaryotic initiation factor 4E (eIF4E)–binding proteins (4E-BP1) is a downstream peptide in mammalian target of rapamycin (mTOR) critical pathway, which is a crucial regulator for cancer cells (Wolfson and Sabatini., 2017; Song et al., 2019; Woodcock et al., 2019), and belongs to a family of translation repressor proteins (Rojo et al., 2007; She et al., 2010).