In summary, Fe(PIP)3SO4, an Fe (II)-based polypyridine complex, exhibited favorable anticancer activities against gliomas by regulating expression level of 4E-BP1 and p-53, making it a promising and low-toxicity chemotherapeutic agent to antagonize glioblastoma and overcome BBB. The gene discussed is EIF4EBP1; the disease is glioblastoma.