Our results were consistent with previous studies from our group (Traves et al., 2013) in which hispanolone derivatives (including α-H) have been described to induce apoptosis through activation of death receptor and mitochondria pathway as well as modulation of expression levels of anti-apoptotic proteins (Bcl-2) and pro-apoptotic proteins (Bax) in several carcinoma lines. Here, BAX is linked to carcinoma.