For example, sorafenib which demonstrated the RF value of 1.08 in this study are having the capacity to trigger autophagic cells death in hepatocellular carcinoma and gastrointestinal cancer cells mediated by the inhibition of myeloid cells leukemia-1 (MCL-1) and activation of CD95, respectively (Park et al., 2010; Tai et al., 2013). This evidence concerns the gene MCL1 and hepatocellular carcinoma.