Amongst the 3 upregulated genes, CYP2C19 and NAT2 have long been reported to participate in the failure of anticancer agents treatment or the increased occurrence of cancers (Hein et al., 1993; Hein et al., 2000; Rochat, 2005; AbuHammad and Zihlif, 2013). The gene discussed is NAT2; the disease is cancer.