BAK1 and cancer: Intriguingly, the expression of the proto-oncogenes responsible for cell growth and proliferation, including KRAS, HRAS, NRAS, MYB, and platelet derived growth factor subunit B (PDGFB), in DLD-1 BAX–BAK DKO cells were suppressed when compared with the WT control (Figure S4), which suggested that the development of drug-resistant phenotype may not necessary be associated with the proliferation ability of the cancer cells, implicating the critical role of apoptosis resistance in such issue.