To further confirm whether the altered expression of these 10 genes (NFKBIβ, EGFR, FOS, NFKB1, PPARα, RXRα, RXRβ, TPMT, UGCG, and XPC) in DLD-1 colon cancer cells would affect their responsiveness towards chemotherapeutics agents, MTT assay was performed to analyze the viability of the transfected cells after etoposide treatment. This evidence concerns the gene XPC and malignant colon neoplasm.