Intriguingly, the expression of the proto-oncogenes responsible for cell growth and proliferation, including KRAS, HRAS, NRAS, MYB, and platelet derived growth factor subunit B (PDGFB), in DLD-1 BAX–BAK DKO cells were suppressed when compared with the WT control (Figure S4), which suggested that the development of drug-resistant phenotype may not necessary be associated with the proliferation ability of the cancer cells, implicating the critical role of apoptosis resistance in such issue. This evidence concerns the gene HRAS and cancer.