EEF2K and Alzheimer disease: Further, two recent studies implicate that abnormal increase of eEF2 phosphorylation (via eEF2K) is linked to AD-associated synaptic failure and neurotoxicity exerted by Aβ (Ma et al., 2014; Jan et al., 2017), and we found similar hyper-phosphorylation of eEF2 in old mice (Figure 2F).