AGT and hypertensive disorder: To better understand the link between estrogen and hypertension, Milner et al. studied the changes in subcellular localization of the glutamate N-Methyl-D-aspartate (NMDA) receptor subunit GluN1 in ERβ-positive neurons of the PVN following slow pressor AngII treatment in males and females using both the senescence and AOF models (Marques-Lopes et al., 2014, 2017).