An increasing number of studies using either the senescence or OVX models have shown that in “post-menopause-like” state females are more susceptible to AngII-induced hypertension to a magnitude similar to that observed in males (Tiwari et al., 2009; Capone et al., 2012; Sandberg and Ji, 2012; Coleman et al., 2013; Marques-Lopes et al., 2014, 2015). Here, AGT is linked to hypertensive disorder.