Neuropathologically, AD is characterized by progressive deposition of parenchymal senile plaques comprised of amyloid-β (Aβ) protein, intracellular neurofibrillary tangles (NFTs) of abnormal phosphorylated tau, and chronic gliosis primarily in the hippocampus and neocortex (Price et al., 1991; Braak and Braak, 1997; Montine et al., 2012; Au et al., 2016; Scheltens et al., 2016; Lane et al., 2018), brain areas critical for learning and memory. Here, MAPT is linked to Alzheimer disease.