AGT and Hypertension: It is now established that young female mice are protected from slow pressor Angiotensin II (AngII)-induced hypertension compared to age-matched males (Girouard et al., 2009; Xue et al., 2009, 2013, 2014; Marques-Lopes et al., 2014, 2015, 2017; Van Kempen et al., 2015).