For instance, the most well-established genetic risk factors for late onset AD is the presence of a common allele ε4 in the APOE gene (Corder et al., 1993; Coon et al., 2007), which encodes for a lipid-binding protein crucial in triglycerides and cholesterol transport to neurons (Puglielli et al., 2003; Bu, 2009; Leduc et al., 2010). This evidence concerns the gene APOE and Alzheimer disease.