In accordance, it has been demonstrated that plasma Aβ induces insulin resistance in hepatocytes by activating Janus Kinase 2 (JAK2)/STAT3/Suppressor of Cytokine Signaling-1 (SOCS-1) signaling pathway in APP/PS1 mice, suggesting an important role of peripheral Aβ in the regulation of glucose metabolism (Zhang et al., 2013). Here, JAK2 is linked to Insulin resistance.