APOE and obesity due to melanocortin 4 receptor deficiency: On the other hand, representing the remaining 97%, the late onset form of AD (LOAD) which is associated with advanced age, mutations of the apolipoprotein E (APOE) ε4 allele, hypertension and hyperlipidaemia, as well as with coronary disease, T2DM and obesity among other less determinant factors.