MAPT and Alzheimer disease: Interestingly, AD preclinical models show that preventing IR inhibition enhances Protein kinase B (AKT) signaling, which is involved in cell proliferation, cell growth, protein synthesis and inhibition of apoptosis, but also in the hyperphosphorylation of Tau through the control of the glycogen synthase kinase 3β (GSK3β; El Khoury et al., 2014).