LRRK2 and Parkinson disease: Studies have found (Belarbi et al., 2010; Alcalay et al., 2013; Gatto et al., 2013; Sierra et al., 2017; Gunzler et al., 2018; Mestre et al., 2018) that the clinical features of PD patients with the LRRK2:G2019S variation included a high average age at onset, more female patients, long disease course, starting mainly in the lower limbs, abnormal posture and gait disorders, and more depression, hallucinations, sleep disorders and cognitive disorders.