Of note, products of both amyloidogenic [Aβ(1–42)] and non-amyloidogenic (sAPPα) APP processing have been shown to enhance mGluR-dependent protein synthesis and contribute to hyperexcitability and altered synaptic plasticity in FXS (Renner et al., 2010; Westmark et al., 2011b, 2016a; Pasciuto et al., 2015). Here, APP is linked to fragile X syndrome.