Interestingly, an AD risk component identified through microarray analysis and subsequent GWAS studies, SORLA (Lambert et al., 2013) was previously shown to bind and traffic APP, and promote its distribution to non-amyloidogenic subcellular compartments such as the Golgi (Andersen et al., 2005) and cell surface (Huang et al., 2016). This evidence concerns the gene APP and Alzheimer disease.