What is more, elevated expression of a mammalian L-type Ca2+ channel (CaV1.2) was observed in a neuroblastoma cell line following transgenic Aβ42 expression; this resulted in reduced cell viability and six-fold increase in Ca2+ influx, that could be ameliorated by the L-type Ca2+ channel dihydropyridine blockers, nimodipine and isradipine (Copenhaver et al., 2011). The gene discussed is CACNA1C; the disease is neuroblastoma.