MAPT and early-onset autosomal dominant Alzheimer disease: Alzheimer’s disease and tauopathies have been modeled in Drosophila (Iijima-Ando and Iijima, 2010; Wentzell and Kretzschmar, 2010; Papanikolopoulou and Skoulakis, 2011), with targeted neuronal expression of human 0N4R tau causing neurodegeneration, shortened lifespan, circadian, sleep and motor deficits (Wittmann et al., 2001; Kerr et al., 2011; Sealey et al., 2017; Buhl et al., 2019; Higham et al., 2019).