APP and Alzheimer disease: This study went on to show that the L-type channel blocker, isradipine could increase survival of Drosophila overexpressing human amyloid precursor protein (APP695), as well as decreasing the accumulation of Aβ and phosphorylated tau in the triple transgenic AD mice (3 × TgAD) which express human Presenilin 1M146V, APPSwedish and tauP30L.