P2RX7 and melanoma: Interestingly, it was shown previously that stimulation of P2X7 with ATP or Bz-ATP triggers VEGF release from primary human monocyte (Hill et al., 2010) and also that VEGF secretion is reduced in P2X7-silenced B16 melanoma cells compared to WT B16 cells (Adinolfi et al., 2012).