P2RX7 and ischemia: The expression of P2X7 on HEK293 (stably transfected with P2X7) or increased expression of P2X7 in astrocyte in the brain of mice with sublethal ischemia, as well as long stimulation by Bz-ATP of primary mouse astrocyte triggers the expression of HIF-1α (Amoroso et al., 2012; Hirayama et al., 2015).