Besides, berberine also showed therapeutic effect toward AD via inhibition of monoamine oxidase B (MAO-B), cholinesterases and β-secretase activities, defense against damage from ROS, and reduction of the amyloid-beta genesis (Asai et al., 2007; Jung et al., 2009; Panahi et al., 2013). The gene discussed is MAOB; the disease is Alzheimer disease.