Besides CSF 14-3-3 in WB and positive RT-QuIC in CSF and other tissues for PrP pathological seeding activity, the protein tau in CSF, usually measured by ELISA, is another potent biomarker for diagnosis for human prion diseases, particularly for sCJD (Matsui et al., 2011; Leitao et al., 2016; Humpel and Benke, 2017). The gene discussed is MAPT; the disease is prion disease.