CASP3 and Alzheimer disease: In particular we found that the number of caspase-3 positive retinal ganglion cells in each field of view (FOV) examined was increased compared to age matched controls (AD: 11.4 ± 2.2%, n = 17/6 fields/patients; CTRL: 6.0 ± 1.0%, n = 18/6 fields/control; p < 0.05; Figure 2B) These results indicated that the AD retinal IL is more subject to neuronal death thus suggesting that visual defects and optic nerve thinning observed in AD may rely on retinal ganglion cells neurodegeneration.