We here report that AD patients retina show, in addition to the presence of Aβ plaques and pTau tangles, ganglion neuron degeneration, astrogliosis, microglia activation, and up-regulation of specific disease associated neuron-to-glia signaling proteins, such as IL-1β, C3, OPN and TREM2. Here, TREM2 is linked to Alzheimer disease.