Moreover, the misregulated expression of glia released soluble factors in AD has been linked to disease associated microglia, and to microglia induced NLRP3 inflammasome and complement activation (Heneka et al., 2013; Sheedy et al., 2013; Lian et al., 2015; Iram et al., 2016) and synaptic loss (Hong et al., 2016). This evidence concerns the gene NLRP3 and Alzheimer disease.